Endocrine Abstracts

Introduction: Serum calcium (Ca) is a major regulator of PTH secretion, but serum magnesium (Mg)also can modulate PTH secretion. Intracellular Mg depletion impairs the ability of the parathyroid to secrete PTH,which subsequently cause fall in the serum Ca concentration.Case report: A 67 year old male patient was admitted to intensive care unit because of disturbance of consciousness, due to suspected hepatic encephalopathy. In his previous history, he ha...

Background: Acute intermittent porphyria (AIP) is characterized by attacks of abdominal pain and neuropsychiatric symptoms. This disease is more frequently and more severely affecting women. Hem deficiency in the liver of AIP patients stimulates an increase in ALA-synthase which triggers an escalating metabolic chain reaction, leading to an increase in the porphyrin content. Treatment of AIP is carbohydrate-rich diet and by treating the attacks with intravenous infusions of gl...

Cushing’s disease (CD) is a rare disorder caused by an increased secretion of adrenocorticotropin hormone (ACTH) from the anterior pituitary gland, usually as a result of pituitary adenoma. Transsphenoidal tumour resection is the best first line therapy option for these patients but 10–30% of them fail to achieve remission and need further treatment modalities to eliminate hypercortisolemia. Long-term outcomes and possible impacts on quality of life in these patients...

Introduction: Polyglandular autoimmune syndrome type II (PGA-II) is the most common immunoendocrinopathy syndrome, characterized by the obligatory occurrence of Addison disease in combination with thyroid autoimmune diseases and/or type 1 diabetes mellitus. This case report presents coexistence of mosaic Turner syndrome and pituitary micoradenoma in patient with PGA-II.Case report: A 30-year-old women underwent IVF for four times, with no success (always...

Post-surgical hypoparathyroidism is most common cause of hypoparathyroidism develops after accidental damage to or removal of the parathyroid glands during surgery. Heart arrhythmias and fainting, even heart failure is reversible complications of hypoparathyroidism, due to low calcium levels. Long QT (LQT) interval may lead to syncope, cardiac arrest, or sudden death. The goal of hypoparathyrodisms treatment is to relieve symptoms and to normalize levels of calcium and phospho...

Background: Most common tumors in the suprasellar region are adenomas of the pituitary gland, craniopharyngiomas, cystic lesions (Rathke’s cleft cysts). Supraselar meningiomas are rare and slow-growing tumors that usually arise from the tuberculum sellae or the chiasmatic sulcus. These tumors frequently invade the sella turcica because that they are mistaken for a pituitary tumor.Methods: A case seriesResults: We present a two...

Aim: To present a patient with all manifestations of long-term unsubstituted hypothyroidism-from alopecia to myxedema megacolon.Case: Sixty-one-old year women was admitted in ICU due to disturbance of consciousness, respiratory failure and electrolyte imbalance. Sopor, expressed alopecia, dry, flaky, pail skin, generalized edema, lung stasis and pericardial friction. A laboratory parameters pointed to the presence of normocytic normochromic anemia, hypon...

Multiple dose adjustments can sometimes be inefficient in reaching eumetabolic state in patients with hypothyroidism treated by levothyroxine sodium tablets.We report a case of 46-year-old female who has been on levothyroxine sodium tablet replacement therapy since 2004 without ever reaching eumetabolic state. As sellar MRI ruled out pituitary adenoma, investigation perform absorption test with 300 mg levothyroxine and test was positive in aspect of pres...

A pheochromocytoma is a rare, catecholamine-secreting tumor that may precipitate life-threatening hypertension. The tumor is malignant in 10% of cases. Although pheochromocytoma has classically been associated with von Hippel-Lindau (VHL) syndrome, multiple endocrine neoplasia type 2 (MEN 2), and neurofibromatosis type 1 (NF1) there are now 10 genes that have been identified as sites of mutations leading to pheochromocytoma.Method and materials A case re...

Introduction: Gestational diabetes(GDM) is a kind of diabetes that can happen during pregnancy. Many women who have GDM, get type 2 diabetes later in life. GDM is more likely for women who are overweight, women with family members who have type 2 diabetes and women who are American Indian. During pregnancy of healthy women, it is usual for blood lipids to increase significantly. Total cholesterol, HDL- and LDL-cholesterol increase 25-50%, triglycerides increase twice to four t...